Enzymes That Work Beyond Digestion
When most people hear the word “enzymes,” they think about food digestion. That’s a good start—but it’s only part of the story. There’s a whole category of enzymes known as systemic enzymes, and their job goes far beyond the gut. These powerful proteins circulate in the bloodstream and help modulate inflammation, break down scar tissue, support immune function, and even combat fibrin—an excess protein involved in blood clotting and chronic conditions. If you’ve been struggling with inflammation, fibroids, post-surgical healing, or even chronic fatigue, you might be wondering: what are systemic enzymes good for, really? And how do they differ from the digestive enzymes you take with meals?
In this article, we’ll break it all down in plain English—what systemic enzymes are, how they work, when to use them, and what science says. Plus, we’ll show how Yeastrix Active Enzymes brings the best of both systemic and digestive support in one smart blend.
Key Takeaways
- Systemic enzymes support inflammation reduction, immune modulation, and tissue repair, working beyond digestion.
- They differ from digestive enzymes in function, timing, and location of action within the body.
- Enzymes like serrapeptase and nattokinase specifically help break down fibrin and scar tissue.
- Systemic enzymes can aid conditions like chronic inflammation, uterine fibroids, and gut dysbiosis.
- Yeastrix Active Enzymes offer broad-spectrum support by combining both systemic and digestive enzymes for optimal health benefits.
Estimated reading time: 9 minutes
What Are Systemic Enzymes?
Systemic enzymes are enzymes that work throughout the entire body (the “system”), not just in the digestive tract. While digestive enzymes (like amylase, lipase, and protease) break down food in the stomach and small intestine, systemic enzymes are absorbed into the bloodstream when taken on an empty stomach. From there, they help with inflammation control, immune modulation, tissue repair, detoxification, and more. Think of digestive enzymes as the kitchen crew breaking down a meal, and systemic enzymes as the cleaning crew that shows up afterward to handle deeper repair and cleanup.
Are All Systemic Enzymes Proteolytic?
Most are—but not all. Proteolytic enzymes (also known as proteases) are enzymes that break down proteins into smaller peptides and amino acids. This action is especially useful for clearing out fibrin, scar tissue, and immune complexes—making proteolytic enzymes ideal for systemic repair and inflammation support. These include enzymes like serrapeptase, nattokinase, and high-potency protease.
However, non-proteolytic enzymes—like cellulase, xylanase, beta-glucanase, and chitosanase—can also be used systemically, particularly for biofilm disruption and supporting gut-immune balance. That’s why Yeastrix Active Enzymes includes both proteolytic and non-proteolytic enzymes, giving you broad-spectrum support whether you’re targeting inflammation, candida, or sluggish digestion.
The Difference Between Systemic and Digestive Enzymes
| Feature | Digestive Enzymes | Systemic Enzymes |
|---|---|---|
| Main job | Break down food | Support full-body repair & inflammation modulation |
| Where they work | Stomach and small intestine | Bloodstream and tissues |
| When to take | With meals | On an empty stomach |
| Examples | Amylase, Lipase, Lactase | Serrapeptase, Nattokinase, Protease |
| Conditions they help | Bloating, food intolerance | Inflammation, fibrosis, immune imbalance |
Many enzymes can do both jobs—it depends on timing and formulation.
What Do Systemic Enzymes Do in the Body?
Here’s what science tells us systemic enzymes can do when taken consistently on an empty stomach:
1. Break Down Fibrin
Fibrin is a protein involved in clotting and wound healing, but excess fibrin contributes to scar tissue, poor circulation, and even fibroids. Enzymes like serrapeptase and nattokinase help break down this buildup.
A 2017 study in Biochemistry and Biophysics Reports found that nattokinase significantly reduced fibrin concentration in plasma.
2. Reduce Inflammation
Systemic enzymes like protease, serrapeptase, and nattokinase have been studied for their anti-inflammatory effects. They help break down inflammatory proteins and modulate chemical messengers such as prostaglandins and bradykinin, which play a key role in pain and swelling.
In a 2004 clinical trial published in Clinical Rheumatology, a combination of proteolytic enzymes (trypsin, bromelain, and rutin) was shown to be as effective as diclofenac, a standard NSAID, in reducing osteoarthritis symptoms—with fewer reported side effects.
3. Dissolve Scar Tissue and Cysts
Systemic enzymes are used in protocols for:
- Uterine fibroids
- Endometriosis
- Post-surgical adhesions
They work by breaking down fibrin and necrotic tissue, improving flexibility and reducing pain.
4. Modulate the Immune System
Systemic enzymes help balance the immune system, especially when chronic inflammation or autoimmunity are involved.
Proteolytic enzymes may stimulate macrophages, helping the immune system clear debris and support repair.
(Macrophages are specialized immune cells that act like the body’s cleanup crew — they remove harmful microbes, damaged cells, and waste to help the body heal.)
5. Break Down Biofilms
Biofilms are protective shields bacteria and yeast use to evade the immune system. Enzymes like chitosanase, xylanase, hemicellulase, and beta-glucanase help disrupt these biofilms.
This is critical for candida and SIBO recovery, which is why we include these enzymes in Yeastrix Active Enzymes.
6. Promote Circulation and Heart Health
Nattokinase in particular is known for supporting circulation and blood viscosity. By breaking down fibrin, it may help reduce the risk of poor circulation, clot formation, and cardiovascular strain.
Several studies suggest nattokinase has blood pressure-lowering and blood-thinning effects ( Examine: Does Nattokinase Lower Blood Pressure? )
7. Assist with Detoxification
As enzymes help break down proteins, immune complexes, and debris, the lymphatic system and liver have an easier time clearing waste. This lightens the load on detox organs.
Enzyme support can complement gentle detox protocols without pushing the body too hard.
Conditions Systemic Enzymes May Support
Chronic Inflammation
Whether you have arthritis, skin conditions, or recurring sinus infections, systemic enzymes can support your body’s ability to manage inflammation from the inside out.
Especially helpful for those sensitive to NSAIDs (like ibuprofen or aspirin) or looking for long-term natural solutions.
Uterine Fibroids and Endometriosis
Systemic enzymes can reduce fibrotic tissue and improve pelvic circulation. Combined with hormonal and gut support, they play a role in symptom management and long-term recovery.
Autoimmunity and Fatigue
Conditions like rheumatoid arthritis, Hashimoto’s, or chronic fatigue syndrome often involve immune system confusion and high levels of systemic inflammation. Enzymes may help clear the immune debris, reduce pain, and restore balance.
Candida and Biofilms
Fungal and bacterial overgrowth often hide behind biofilms, making protocols less effective. Including systemic enzymes can improve your outcomes when used with antifungals and a low-sugar diet.
Read our article : Enzymes for Candida Biofilms: What’s Really Going On—and How to Clear It Naturally
Post-Surgical Recovery
Whether recovering from C-section, knee surgery, or dental procedures, enzymes can:
- Reduce swelling and bruising
- Speed tissue repair
- Minimize scar tissue
Skin Conditions
Because systemic inflammation plays a role in eczema, psoriasis, and acne, enzymes may indirectly help by addressing the internal triggers.
Case Study: What Are Systemic Enzymes Good For?
Olivia’s Results Using Yeastrix Two Ways
When Olivia, a 42-year-old graphic designer, reached out to us, she had been quietly suffering with a mix of gut and hormone-related symptoms. Chronic bloating, heavy and painful periods, brain fog, and mid-afternoon crashes were becoming her norm. Her doctor had diagnosed her with uterine fibroids and suspected she might also be dealing with gut dysbiosis, but the only options offered were hormonal medication or surgery—neither of which felt right.
“I felt like I was walking around inflamed all the time—physically and mentally.”
After reading our article on enzyme therapy, Olivia asked,
“What are systemic enzymes good for when you’re dealing with gut and hormone issues at the same time?”
We suggested trying Yeastrix Active Enzymes both systemically and digestively—same formula, two different timing strategies.
How She Used Yeastrix Active Enzymes
Morning and Evening (Systemic Use):
Olivia took 2 capsules on an empty stomach when she woke up, and 2 more before bed. This allowed systemic enzymes like acid-resistant serrapeptase, nattokinase, and protease to enter her bloodstream and begin breaking down fibrin, clearing inflammation, and supporting immune modulation.
With Meals (Digestive Use):
She also took 1 capsule with her two largest meals (lunch and dinner) to help digest carbohydrates, fats, and proteins—and to reduce the heavy bloating she experienced after eating.
Results After 8 Weeks
Within two weeks, Olivia began noticing subtle but encouraging shifts:
- Less bloating and more regular digestion
- Clearer thinking, with reduced brain fog
- Better sleep, and waking with more energy
- Lighter periods, with fewer clots and less pain
By week eight, she described a “lightness” in her body and mind—like inflammation had lifted.
“It’s like my body finally had the tools to clean up the inflammation mess that had been building for years.”
Note: Olivia’s name has been changed to protect her privacy. Model shown is for illustrative purposes only.
Why Her Story Matters
Olivia’s case is a great example of what systemic enzymes are good for in real life—not just easing digestion, but supporting hormone balance, inflammation resolution, and whole-body clarity.
By using the same enzyme blend two different ways, she was able to target both gut-based and systemic issues without overwhelming her routine or budget.
How to Take Systemic Enzymes
- Take on an empty stomach: 30–60 minutes before a meal or 2 hours after
- Start low, go slow: Begin with 1 capsule per day; increase gradually if needed
- Hydrate well: Aim for 6–8 glasses of water daily to flush toxins
- Be consistent: Enzymes work best when taken daily over time
Caution: If you’re on blood thinners, preparing for surgery, or pregnant, consult your practitioner.
About the Yeastrix Active Enzymes Formula
Most systemic enzyme formulas focus only on a few enzymes. Yeastrix Active Enzymes offers something smarter: a broad-spectrum formula for both gut and systemic support.
Key features:
- 500 mg proprietary enzyme blend per capsule
- Includes:
- Amylase, glucoamylase, lipase, diastase, alpha-galactosidase: Carb and fat breakdown
- Beta-glucanase, cellulase, hemicellulase, xylanase, chitosanase: Biofilm and fiber degradation
- Acid-resistant nattokinase and serrapeptase: Targeted systemic action
- Protease: Protein digestion and fibrin degradation
- Bacillus coagulans (1 billion CFU): Gut microbiome support
This formula is ideal for those dealing with:
- Yeast overgrowth or SIBO
- Biofilm and immune challenges
- Chronic inflammation or fibroids
We designed this blend to multitask: support digestion if taken with meals, and go systemic if taken on an empty stomach.
Why Not All Systemic Enzymes Are the Same
Some blends rely heavily on mega-doses of single enzymes like serrapeptase. Others don’t survive stomach acid. Our formula uses acid-resistant enzymes, so they reach your bloodstream intact. Plus, the inclusion of biofilm-disrupting enzymes and a spore probiotic (bacillus coagulans) makes Yeastrix Active Enzymes uniquely comprehensive.
Common Questions About Systemic Enzymes
Can I take systemic enzymes with other supplements? Yes, just avoid taking them with protein powders or food, as they will act digestively instead of systemically.
Do they cause detox symptoms? Sometimes. If enzymes are breaking down a large amount of debris or biofilm, you might feel temporarily tired, achy, or bloated. Back off and build slowly.
How long before I feel a difference? Many people notice improvements within 2–4 weeks. For chronic issues, 2–3 months may be needed to rebuild from the inside.
Should I take breaks? Some practitioners recommend pulsing enzymes or taking weekends off, but many people take them daily without issue. Follow your body’s signals.
Final Thoughts: Are Systemic Enzymes Right for You?
If you’re dealing with inflammation, gut dysbiosis, fibroids, fatigue, or biofilm-related infections, systemic enzymes could be the missing piece. They’re not magic pills, but with consistency, hydration, and smart timing, they can support your body’s ability to reset and heal.
Next Steps
- Read: Do Enzymes Help With Candida Biofilms?
- Shop: Yeastrix Active Enzymes
- Download: Our 7-Day Yeastrix Reset Meal Plan
- Learn: What Causes Chronic Inflammation (and How to Calm It)
This article is intended for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new treatment or supplement, especially if you have a pre-existing medical condition or are taking medication. The recommendations here reflect a naturopathic approach and are not meant to replace conventional care when it is required. Individual results may vary.
Estimated reading time: 10 minutes
